The basic science of opto-acoustics was first discovered in 1880 by Alexander Graham Bell, but the application of this effect was not made practical until the technology for producing stable laser light was refined in the 1970’s. In the late 1990’s, a PhD biophysicist developed the first successful method of combining laser light with the latest ultrasound detection techniques in a safe and effective way, thus providing the first opto-acoustic images in human tissue. This biophysicist became the lead researcher and inventor of opto-acoustics for clinical use, and he, along with many other Seno scientists and engineers, were instrumental in initiating the first commercial product development. Other than Seno Medical Instruments, no other company has demonstrated such a combination of expertise and motivation towards commercialization.